NSC10978 Chemical Properties

Melting point:

58.5°C

Boiling point:

296°C (rough estimate)

Density 

2.2414 (rough estimate)

refractive index 

1.6400 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

White

Safety Information

HS Code 

2904990090

NSC10978 Usage And Synthesis

Chemical Properties

Yellow needle-like or flaky crystals. Melting point 58-59°C, boiling point 296°C, 180°C (2.66kPa), relative density 2.354 (8/4°C), refractive index 1.9853 (111°C). Soluble in ethanol, benzene and acetic acid, insoluble in water. Can sublimate and volatilize with water vapor.

Synthesis

The general procedure for the synthesis of 1,2-dibromo-4-nitrobenzene from 4-nitrophthalic acid was as follows: 4-nitrophthalic acid (1 mmol), bromoisocyanuric acid ester, additives, and solvent (10 ml) were added to a round-bottom flask equipped with a Dimroth condenser (cooled to 10°C). The reaction mixture was heated under magnetic stirring in an oil bath at 120 °C for 60 h under fluorescent room light irradiation (FL). Upon completion of the reaction, the cooled mixture was filtered through a short silica gel pad, washed with 1 M aqueous Na2SO3 solution, dried over Na2SO4, filtered and concentrated in vacuum to give the crude product 1,2-dibromo-4-nitrobenzene. The crude product can be further purified by silica gel chromatography. The experimental results are detailed in Table 6.

References

[1] Patent: WO2017/60905, 2017, A1. Location in patent: Paragraph 00164