LEK 8804
LEK 8804 Basic information
- Product Name:
- LEK 8804
- Synonyms:
-
- LEK 8804
- 9,10-Didehydro-N-(2-propynyl)-6-methylergoline-8-carboxamide
- Ergoline-8-carboxamide, 9,10-didehydro-6-methyl-N-(2-propynyl)-, (8beta)-
- Ergoline-8-carboxamide, 9,10-didehydro-6-methyl-N-(2-propynyl)-, (8β)- (9CI)
- CAS:
- 153415-44-2
- MF:
- C19H19N3O
- MW:
- 305.37
- Mol File:
- 153415-44-2.mol
More
Less
LEK 8804 Chemical Properties
- Boiling point:
- 595.1±50.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- pka
- 13.65±0.20(Predicted)
More
Less
LEK 8804 Usage And Synthesis
Description
LEK 8804 is a 5-HT(1A) receptor agonist and 5-HT(2) receptor antagonist.
Uses
LEK 8804 is a compound with 5-HT1A receptor agonist and 5-HT2 receptor antagonist properties, and has the activity of modulating related receptor-mediated behavioral responses. LEK 8804 can induce spontaneous tail-flick response in rats in a dose-dependent manner, showing complete 5-HT1A agonist activity, and can inhibit 5-HTP-induced head twitch response in mice, probably through antagonism of 5-HT2 receptors rather than agonism of 5-HT1A receptors.
References
[1] Behavioral studies on LEK-8804, a new ergoline derivative with potent 5-HT1A receptor agonist and 5-HT2 receptor antagonist activity DOI:10.1016/0091-3057(94)90014-0