A 65281
A 65281 Basic information
- Product Name:
- A 65281
- Synonyms:
-
- A 65281
- 9-Cyclopropyl-6,8-difluoro-7-(1-piperazinyl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione
- CAS:
- 111279-49-3
- MW:
- 0
- Mol File:
- 111279-49-3.mol
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A 65281 Usage And Synthesis
Description
A 65281 is an antibacterial isothiazoloquinolone. It induces considerable DNA breakage mediated by calf thymus topoisomerase II. A 65281 is a potent inhibitor of the P4-unknotting reaction.
Uses
A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 μg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC50 value of 8 μg/mL[1].
References
[1] Kohlbrenner WE, et al. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36(1):81-6. DOI:10.1128/AAC.36.1.81