SC 67655 Usage And Synthesis

Description

SC 67655 is a peptidomimetic that specifically inhibits human leukocyte antigen DRB10401-restricted T cell proliferation.

Uses

SC 67655 is a potent and stable pentapeptide MHC class II haplotype DR4 (DR4 Dw4 or DRB 1"0401) ligand with an IC50 of 50 nM. SC 67655 can be used for the study of autoimmune diseases[1].

References

[1] S L Woulfe, et al. A peptidomimetic that specifically inhibits human leukocyte antigen DRB1*0401-restricted T cell proliferation. J Pharmacol Exp Ther. 1997 May;281(2):663-9. PMID:9152371
[2] Gunnar J. Hanson, et al. (1996). Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5. , 6(16), 1931-1936.