L 684248 Usage And Synthesis

Description

L 684248 is a LPase inhibitor.

Uses

L-684248 is an inhibitor of human leukocyte elastase (HLE). L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research[1].

References

[1] Underwood DJ, et al. Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes. Biochemistry. 1995 Nov 7;34(44):14344-55. DOI:10.1021/bi00044a011