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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Biochemical Reagents >  Amines, Acids and Salts >  2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)-

2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)-

Basic information Safety Supplier Related

2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)- Basic information

Product Name:
2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)-
Synonyms:
  • 2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)-
  • (Z)-3,4,4-Trifluoro-4-(phenylsulfonyl)-2-buten-1-amine Hydrochloride
  • PXS-6302 hydrochloride
CAS:
2584947-79-3
MF:
C10H10F3NO2S.ClH
MW:
301.71
Mol File:
2584947-79-3.mol
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2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)- Chemical Properties

form 
Solid
color 
White to off-white
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2-Buten-1-amine, 3,4,4-trifluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)- Usage And Synthesis

Uses

PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance[1].

in vivo

PXS-6302 hydrochloride inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury[1].
PXS-6302 hydrochloride (1.5%, oil in water cream; 500 mg cream applied to 16 cm2; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application[1].
PXS-6302 hydrochloride (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application[1].

Animal Model:Porcine excision injury model (female Juvenile pigs, 18-20 kg)[1].
Dosage:0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2
Administration:External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance. Molecular Weight 265.25 Formula C10H10F3NO2S CAS No. 2584947-54-4 SMILES NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F Shipping Room temperature in continental US; may vary elsewhere. Storage Please store the product under the recommended conditions in the Certificate of Analysis. Purity & Documentation Data Sheet (270 KB)Handling Instructions (2659 KB) References [1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]

References

[1] Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. DOI:10.1038/s41467-022-33148-5

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