kievitone Chemical Properties

Boiling point:

639.6±55.0 °C(Predicted)

Density 

1.384±0.06 g/cm3(Predicted)

pka

7.65±0.40(Predicted)

LogP

4.600 (est)

kievitone Usage And Synthesis

Uses

Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity[1][2].

Definition

ChEBI: Kievitone is a hydroxyisoflavanone that is isoflavanone with hydroxy substituents at positions 5, 7, 2' and 4' and a prenyl group at position 8. It has a role as a phytoalexin, an antineoplastic agent and a metabolite. It is a conjugate acid of a kievitone-7-olate.

References

[1] Smith DA, et, al. Kievitone: the principal antifungal component of “substance II” isolated from Rhizoctonia-infected bean tissues. 1973 Apr;3(14):179-84.
[2] Hoffman R. Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein. Biochem Biophys Res Commun. 1995 Jun 15;211(2):600-6. DOI:10.1006/bbrc.1995.1855

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