PD 132301-2 Chemical Properties

storage temp. 

4°C, away from moisture

solubility 

DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic)| (insoluble)

form 

Solid

color 

White to off-white

Water Solubility 

Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

PD 132301-2 Usage And Synthesis

Uses

Nevanimibe Hydrochloride can be used for combinatory treatment strategies of cancer based on RNA polymerase I inhibition.

Biological Activity

ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) th at reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed r at models. In addition, ATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH), and Cushingμs syndrome (CS).

PD 132301-2(133825-81-7)Related Product Information

• Beryllium