Ro 31-0052 Chemical Properties

Boiling point:

547.3±60.0 °C(Predicted)

Density 

1.51±0.1 g/cm3(Predicted)

pka

14.06±0.20(Predicted)

Ro 31-0052 Usage And Synthesis

Uses

Ro 31-0052 is a basic radiation sensitizer, a 3'-hydroxypiperidine analog of Ro 03-8799, with improved hydrophilicity. This type of designed radiation sensitizer has better pharmacokinetic properties and has the potential to replace clinically used Misonidazole (HY-105061) and Metronidazole (HY-B0318)[1].

References

[1] Dennis MF, Stratford MR, Wardman P, Watts ME. Cellular uptake of misonidazole and analogues with acidic or basic functions. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jun;47(6):629-43. DOI:10.1080/09553008514550871
[2] Stratford M R L, et al. Pharmacokinetic studies on some novel (2-nitro-1-imidazolyl) propanolamine radiosensitizers[J]. Advanced Topics on Radiosensitizers of Hypoxic Cells, 1982: 165-169.