PD 121373 Chemical Properties

Boiling point:

643.7±55.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

pka

8.78±0.20(Predicted)

PD 121373 Usage And Synthesis

Description

PD 121373 is a Benzothiopyrano-indazole cpd. The benzothiopyranoindazoles are potent inhibitors of nucleic acid synthesis, reducing both DNA and RNA synthesis to the same extent at similar concentrations. Like other known intercalators, these compounds produced DNA single- and double-strand breaks in a time- and concentration-dependent manner in L1210 cells.

Uses

PD 121373 is a DNA complexing agent with antitumor activity. PD 121373 can bind tightly to DNA and RNA and inhibit the synthesis of DNA and RNA. The IC50 values of PD 121373 for inhibiting DNA and RNA synthesis in L1210 cells are 0.5 μM and 0.3 μM, respectively[1].

References

[1] DAVID W, et al. "Biochemical pharmacology and DNA-drug interactions by Cl-958, a new antitumor intercalator derived from a series of substituted 2H-[1] benzothiopyrano [4, 3, 2-cd] indazoles." Molecular pharmacology 33.1 (1988): 84-92. PMID:2447481