poststatin
poststatin Basic information
- Product Name:
- poststatin
- Synonyms:
-
- poststatin
- L-Val-L-Val-[(3S)-2-Oxo-3-amino*pentanoyl]-D-Leu-L-Val-OH
- N-[N-[(S)-3-[(N-L-Valyl-L-valyl)amino]-1,2-dioxopentyl]-D-leucyl]-L-valine
- L-Valine, L-valyl-L-valyl-(3S)-3-amino-2-oxopentanoyl-D-leucyl-
- CAS:
- 135219-43-1
- MF:
- C26H47N5O7
- MW:
- 541.68
- Mol File:
- 135219-43-1.mol
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poststatin Chemical Properties
- Melting point:
- 161-165 °C
- Density
- 1.127±0.06 g/cm3(Predicted)
- pka
- 3.26±0.10(Predicted)
- Sequence
- Val-Val-{Oaa}-{d-Leu}-Val
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poststatin Usage And Synthesis
Uses
Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine[1][2].
References
[1] T Aoyagi, et al. Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1991 Sep;44(9):949-55. DOI:10.7164/antibiotics.44.949
[2] M Majima, et al. Poststatin, a novel inhibitor of bradykinin-degrading enzymes in rat urine. Eur J Pharmacol. 1993 Mar 2;232(2-3):181-90. DOI:10.1016/0014-2999(93)90772-a
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