A 62198
A 62198 Basic information
- Product Name:
- A 62198
- Synonyms:
-
- 5-Azido-1-cyclohexyl-1,2,5-trideoxy-2-[[N-[N-(2-methyl-1-oxopropyl)-L-phenylalanyl]-L-histidyl]amino]-L-arabino-pentitol
- A 62198
- N-[1-[[1-[(5-azido-1-cyclohexyl-3,4-dihydroxy-pentan-2-yl)carbamoyl]-2-(3H-imidazol-4-yl)ethyl]carbamoyl]-2-phenyl-ethyl]-2-methyl-propanamide
- Reaxys ID: 26144718
- CAS:
- 117978-26-4
- MF:
- C30H44N8O5
- MW:
- 0
- Mol File:
- 117978-26-4.mol
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A 62198 Usage And Synthesis
Description
A 62198 is a potent and selective renin inhibitor. A-62198 induced a dose-dependent fall in mean arterial blood pressure (MAP) when administered as an i.v. bolus to anesthetized, salt-depleted monkeys. It has potential as a hypotensive agent.
Uses
A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses[1].
References
[1] Cardiovascular actions of the primate-selective renin inhibitor, A-62198 PMID:3047366