L 368935
L 368935 Basic information
- Product Name:
- L 368935
- Synonyms:
-
- L 368935
- 935
- Urea, N-[(3R)-2,3-dihydro-1-(2-methylpropyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-[3-(1H-tetrazol-5-yl)phenyl]- (9CI)
- CAS:
- 145878-31-5
- MF:
- C27H26N8O2
- MW:
- 494.55
- Mol File:
- 145878-31-5.mol
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L 368935 Chemical Properties
- Density
- 1.37±0.1 g/cm3(Predicted)
- pka
- 4.16±0.10(Predicted)
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L 368935 Usage And Synthesis
Description
L 368935 is a cholecystokinin receptor antagonist.
Uses
L 368935 is a cholecystokinin B receptor (CCKB receptor) antagonist. L 368935 is a brain-penetrant and centrally active compound[1][2].
References
[1] Use of ex vivo binding to estimate brain penetration and central activity of CCK-B antagonists DOI:10.1111/j.1749-6632.1994.tb44093.x
[2] Patel S, et al. Measurement of central nervous system activity of systemically administered CCKB receptor antagonists by ex vivo binding. Eur J Pharmacol. 1994 Mar 3;253(3):237-44. DOI:10.1016/0014-2999(94)90197-x