eckol
eckol Basic information
- Product Name:
- eckol
- Synonyms:
-
- eckol
- 1-(Resorcinol-5-yloxy)-2,4,7,9-tetrahydroxydibenzo-p-dioxin
- 4-(3,5-Dihydroxyphenoxy)dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol
- 4-(3,5-Dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol
- Dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-
- Acanthol
- CAS:
- 88798-74-7
- MF:
- C18H12O9
- MW:
- 372.28
- Mol File:
- 88798-74-7.mol
eckol Chemical Properties
- Melting point:
- 243-244 °C
- Boiling point:
- 685.5±55.0 °C(Predicted)
- Density
- 1.778±0.06 g/cm3(Predicted)
- pka
- 8.06±0.20(Predicted)
eckol Usage And Synthesis
Uses
Eckol is a polyphenolic compound that can be used as a potential drug candidate for treatment of Alzheimer''s disease. Eckol also enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells.
Definition
ChEBI: A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.
in vivo
Foliar application of Eckol (1 μM) significantly enhanced shoot and root length, shoot and root fresh and dry weight, leaf area and leaf number[2].
Eckol (50 or 100 μg/mouse; intradermal; once) reduces allergic inflammatory responses in the passive cutaneous anaphylaxis (PCA)-induced mice[3].
| Animal Model: | BALB/c mice (8 weeks old), IgE/BSA-induced passive cutaneous anaphylaxis (PCA) model[3] |
| Dosage: | 50 or 100 μg/mouse |
| Administration: | Intradermal injection, applied on mice ear 2 h prior to anaphylaxis induction |
| Result: | Reduced allergic inflammatory responses. |
IC 50
hMAO-A: 7.20 μM (IC50); hMAO-B: 83.44 μM (IC50); H1N1: 89.5 μM (IC50)
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