LY 178002
LY 178002 Basic information
- Product Name:
- LY 178002
- Synonyms:
-
- LY 178002
- 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]thiazolidin-4-one
- 4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
- CAS:
- 107889-32-7
- MF:
- C18H25NO2S
- MW:
- 319.46
- Mol File:
- 107889-32-7.mol
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LY 178002 Chemical Properties
- Boiling point:
- 489.9±45.0 °C(Predicted)
- Density
- 1.139±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 11.15±0.50(Predicted)
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LY 178002 Usage And Synthesis
Uses
LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.
in vivo
LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].
IC 50
5-LPO: 0.6 μM (IC50); PLA2: 6.3 μM (IC50); FCO: 4.2 μM (IC50); Cyclooxygenase
References
[1] Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. DOI:10.1007/BF01972804
LY 178002Supplier
Fan De(Beijing) Biotechnology Co., Ltd.
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- 15911056312
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Jinan Jiuli Biotechnology Co. , Ltd.
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- 15865264761
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 15801484223;
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
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- 4008200310
- marketing@tsbiochem.com