glycyl-glycyl-cysteine Chemical Properties

pka

pK1:2.71;pK2:2.71;pK3:7.94;pK4:7.94 (35°C)

Sequence

H-Gly-Gly-Cys-OH

glycyl-glycyl-cysteine Usage And Synthesis

Uses

Glycylglycylcysteine is a Thrombin Activatable Fibrinolysis Inhibitor (TAFI) inhibitor with a Ki of 0.99 μM and a IC50 of 9.4 μM in TAFI substrate assays. TAFI is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin[1].

Definition

ChEBI: Gly-Gly-Cys is an oligopeptide.

References

[1] Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71. DOI:10.1016/j.thromres.2004.12.023

glycyl-glycyl-cysteine(95416-30-1)Related Product Information

• H-GLY-GLY-GLU-ALA-OH
• H-GLY-GLY-ASP-ALA-OH
• H-GLY-GLY-PRO-ALA-OH
• H-GLY-GLY-SAR-OH
• H-GLY-GLY-GLU-OH
• Gly-Gly-Leu
• H-GLY-GLY-MET-OH
• H-Gly-Gly-Lys-Ala-Ala-OH
• Glycylglycyl-L-isoleucine
• H-GLY-GLY-HIS-ALA-OH
• glycyl-glycyl-proline
• H-GLY-GLY-GLN-OH
• H-GLY-GLY-TRP-OH
• H-Gly-Gly-Lys-OH