LY 190388
LY 190388 Basic information
- Product Name:
- LY 190388
- Synonyms:
-
- LY 190388
- D-Valine, L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl- (9CI)
- CAS:
- 105496-35-3
- MF:
- C30H41N5O7S
- MW:
- 615.74
- Mol File:
- 105496-35-3.mol
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LY 190388 Chemical Properties
- Boiling point:
- 1005.8±65.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- pka
- 3.35±0.10(Predicted)
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LY 190388 Usage And Synthesis
Description
LY 190388 is a penicillamine-containing enkephalin analog. It is an mu receptor agonist that produces analgesia..
Uses
LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced[1].
References
[1] Comparison of two penicillamine-containing enkephalins: mu, not delta, activity produces analgesia