NSC 290205
NSC 290205 Basic information
- Product Name:
- NSC 290205
- Synonyms:
-
- NSC 290205
- 3β-[[[4-[Bis(2-chloroethyl)amino]phenyl]acetyl]oxy]-17a-aza-D-homo-5α-androstan-17-one
- DAL-8
- N-S-90205
- NSC-620482
- Lactandrate
- CAS:
- 43000-65-3
- MF:
- C31H44Cl2N2O3
- MW:
- 563.59866
- Mol File:
- 43000-65-3.mol
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NSC 290205 Usage And Synthesis
Uses
Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1[1].
References
[1] Trafalis DT, et al. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. DOI:10.1007/s10549-005-9083-x