PD 132002
PD 132002 Basic information
- Product Name:
- PD 132002
- Synonyms:
-
- PD 132002
- 3-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino]-3-oxo-2-[(S)-2-(4-morpholinylsulfonylamino)-3-phenylpropanoylamino]propionic acid methyl ester
- L-Serinamide, N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-O-methyl-3-oxo-, [1S-(1R*,2S*,3R*)]- (9CI)
- CAS:
- 134452-04-3
- MF:
- C31H50N4O9S
- MW:
- 654.82
- Mol File:
- 134452-04-3.mol
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PD 132002 Chemical Properties
- Density
- 1.28±0.1 g/cm3(Predicted)
- pka
- 10.87±0.20(Predicted)
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PD 132002 Usage And Synthesis
Description
PD 132002 is a renin inhibitor. Studies with PD 132002 show that the dissociation sometimes observed in studies with renin inhibitors between changes in BP (blood pressure) and PRA (plasma renin activity) may be attributed to the assay used to determine PRA.
Uses
PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].
References
[1] J T Repine, et al. Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. J Med Chem. 1991 Jul;34(7):1935-43. DOI:10.1021/jm00111a002