NNC 687
NNC 687 Basic information
- Product Name:
- NNC 687
- Synonyms:
-
- NNC 687
- ADX10061
- ADX-10061
- CEE-03-310
- CEE-310
- NNC-01-0687
- ADX10061,ADX 10061
- CAS:
- 128022-68-4
- MF:
- C19H20N2O4
- MW:
- 340.3731
- Mol File:
- 128022-68-4.mol
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NNC 687 Usage And Synthesis
Uses
ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the Ki values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT2 receptor, respectively. ADX-10061 can be used for study of schizophrenia[1].
IC 50
D1 Receptor: 5.8 nM (Ki); D2 Receptor: > ＞10 000 nM (Ki)
References
[1] Andersen PH, et al. NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists. Eur J Pharmacol. 1992;219(1):45-52. DOI:10.1016/0014-2999(92)90578-r