CGP 31358 Chemical Properties

Boiling point:

562.6±60.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

pka

14.56±0.50(Predicted)

CGP 31358 Usage And Synthesis

Uses

CGP 31358 is an anticonvulsant agent that binds to a site on the NMDA receptor complex that is coupled to both the transmitter recognition site and to the channel domain. CGP 31358 inhibits the binding of L-Glutamate to the NMDA receptor complex with an IC50 of 53 μM[1].

IC 50

NMDA Receptor

References

[1] J Baud, et al. CGP 31358 binds to a site on the NMDA receptor that is coupled to both the transmitter recognition site and the channel domain. Neurosci Lett. 1989 Dec 15;107(1-3):184-8. DOI:10.1016/0304-3940(89)90814-8