Basic information Safety Supplier Related

saquayamycin B

Basic information Safety Supplier Related

saquayamycin B Basic information

Product Name:
saquayamycin B
Synonyms:
  • saquayamycin B
  • 9-(2,9-dimethyl-3-oxo-4,4a,5a,6,7,9,9a,10a-octahydrodipyrano[4,2-a:4',3'-e][1,4]dioxin-7-yl)-4a,8,12b-trihydroxy-3-methyl-3-[6-methyl-5-[(6-methyl-5-oxo-2H-pyran-2-yl)oxy]oxan-2-yl]oxy-2,4-dihydrobenzo[a]anthracene-1,7,12-trione
CAS:
99260-67-0
MF:
C43H48O16
MW:
820.836
Mol File:
99260-67-0.mol
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saquayamycin B Usage And Synthesis

Description

Saquayamycin B is a glycoside of aquayamycin that acts on Gram-positive bacteria and inhibits the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.

Uses

Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI50 values of 12.2 and 15.2 μM respectively [1].

References

[1] Mohamed S Abdelfattah, et al. Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002. J Nat Prod. 2008 Sep;71(9):1569-73. DOI:10.1021/np800281f

saquayamycin BSupplier

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