BK 218
BK 218 Basic information
- Product Name:
- BK 218
- Synonyms:
-
- BK 218
- CAS:
- 110008-56-5
- MF:
- C15H15ClN7NaO5S2
- MW:
- 495.89
- Mol File:
- 110008-56-5.mol
BK 218 Usage And Synthesis
Description
BK 218 is a novel cephalosporin with a dual route of administration and spectrum of activity most similar to that of second-generation cephalosporins. BK-218 was active against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis but strains resistant to penicillins had higher MICs.
Uses
BK-218 is an orally active cephalosporin antibiotic that binds to penicillin-binding proteins (PBPs) and has a greater inhibitory effect than Cephalexin (HY-B0200) and Cefoxitin (HY-B1825). BK-218 has similar antibacterial activity to Cefamandole (HY-B1128) and can be used in the development of antibacterial drugs[1].
References
[1] Szabo I, et al. In vitro investigation of BK-218, a new oral and parenteral cephalosporin[J]. Antimicrobial agents and chemotherapy, 1990, 34(2): 349-354. DOI:10.1128/AAC.34.2.349