KB 5492
KB 5492 Basic information
- Product Name:
- KB 5492
- Synonyms:
-
- KB 5492
- KB-5492 anhydrous
- KB 5492 anhydrous,KB5492 anhydrous
- 1-(3,4,5-Trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine
- CAS:
- 129200-10-8
- MF:
- C27H34N2O10
- MW:
- 546.57
- Mol File:
- 129200-10-8.mol
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KB 5492 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (457.40 mM)
- form
- Solid
- color
- White to off-white
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KB 5492 Usage And Synthesis
Uses
KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent[1][2].
in vivo
KB-5492 (200?mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa[2].
| Animal Model: | Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage[2] |
| Dosage: | 200?mg/kg |
| Administration: | Oral gavage |
| Result: | Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. |
References
[1] Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8. DOI:10.1016/0014-2999(94)90558-4
[2] Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64(1): 41-7. DOI:10.1254/jjp.64.41
KB 5492Supplier
Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
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Shanghai Hongye Biotechnology Co. Ltd
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- 400-9205774
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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- 18818260767
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 15801484223;
- psaitong@jm-bio.com