6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties

Melting point:

207 °C (decomp)

Boiling point:

437.4±25.0 °C(Predicted)

Density 

1.609±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

pka

4.37±0.30(Predicted)

color 

Light brown to brown

6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID Usage And Synthesis

Uses

DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors[1].

References

[1] Sparey T, et al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3386-91. DOI:10.1016/j.bmcl.2008.04.020