3-Bromo-2-methylbenzaldehyde Chemical Properties

Boiling point:

255.3±20.0 °C(Predicted)

Density 

1.490±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

fused solid

color 

Clear, orange/amber liquid

Safety Information

HS Code 

2913000090

3-Bromo-2-methylbenzaldehyde Usage And Synthesis

Synthesis

(3-Bromo-2-methylphenyl)methanol (24 g, 119 mmol) was dissolved in dichloromethane (240 mL) and manganese (IV) oxide (103 g, 1.2 mol). After stirring overnight, TLC showed no starting material. The reaction mixture was evaporated with silica gel and loaded on a small silica gel column. After evaporation, the product was eluted with hexane:ethyl acetate (10:1) to give pure aldehyde 3-bromo-2-methylbenzaldehyde (18.6 g).

References

[1] Patent: US2010/160303, 2010, A1. Location in patent: Page/Page column 36
[2] Journal of the American Chemical Society,
[3] Journal of the American Chemical Society, 2009, vol. 131, p. 1410 - 1412
[4] Journal of the American Chemical Society, 2010, vol. 132, # 1, p. 371 - 383
[5] Patent: WO2010/143733, 2010, A1. Location in patent: Page/Page column 347-348