5'-O-Trityl-2'-deoxyuridine
5'-O-Trityl-2'-deoxyuridine Basic information
- Product Name:
- 5'-O-Trityl-2'-deoxyuridine
- Synonyms:
-
- 5'-O-Trityl-2'-deoxyuridine
- Trt-dU
- 2'-Deoxy-5'-O-(triphenylmethyl)uridine
- 2'-Deoxy-5'-O-trityluridine
- NSC 375393
- 5'-O-Trt-2'-deoxyuridine
- 5'-O-Triphenylmethyl-2'-deoxyuridine
- 5'-Trt-2'-deoxyuridine
- CAS:
- 14270-73-6
- MF:
- C28H26N2O5
- MW:
- 470.52
- Mol File:
- 14270-73-6.mol
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5'-O-Trityl-2'-deoxyuridine Chemical Properties
- Melting point:
- 204-205 °C
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.39±0.10(Predicted)
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5'-O-Trityl-2'-deoxyuridine Usage And Synthesis
Uses
5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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