L-PHENYLALANINE-2-D1 Chemical Properties

Melting point:

270-275°C (dec.) (lit.)

form 

solid

optical activity

[α]25/D -33.0°, c =1 in H2O

InChI

1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1/i8D

InChIKey

COLNVLDHVKWLRT-ZXEPEWCSSA-N

SMILES

[2H][C@](N)(Cc1ccccc1)C(O)=O

CAS Number Unlabeled

63-91-2

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

L-PHENYLALANINE-2-D1 Usage And Synthesis

Uses

L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

IC 50

NMDA Receptor

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110

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