D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE TRIPOTASSIUM SALT Chemical Properties

storage temp. 

-20°C

solubility 

PBS pH 7.2: >50 mg/ml

form 

A lyophilized powder

color 

White to off-white

Safety Information

WGK Germany 

3

D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE TRIPOTASSIUM SALT Usage And Synthesis

Uses

D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2)[1].

References

[1] D M Gou, et al. D-myo-inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization. Bioorg Med Chem. 1994 Jan;2(1):7-13. DOI:10.1016/s0968-0896(00)82196-3
[2] M E Cifuentes, et al. D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes. J Biol Chem. 1994 Jan 21;269(3):1945-8. PMID:8294445