BOC-GLY-GLY-PHE-GLY-OH Chemical Properties

Boiling point:

838.6±65.0 °C(Predicted)

Density 

1.263±0.06 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

DMSO : ≥ 100 mg/mL (229.12 mM)|

pka

3.32±0.10(Predicted)

form 

Solid

color 

White to off-white

Water Solubility 

Water : 25 mg/mL (57.28 mM; Need ultrasonic)

Sequence

Boc-Gly-Gly-Phe-Gly-OH

InChIKey

PTUJJIPXBJJLLV-AWEZNQCLSA-N

SMILES

C(O)(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(OC(C)(C)C)=O

BOC-GLY-GLY-PHE-GLY-OH Usage And Synthesis

Description

Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

Uses

Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

IC 50

Cleavable Linker

References

[1] Dernovics M, et al., Synthesis and application of a Sec2-containing oligopeptide for method evaluation purposes in selenium speciation. Talanta. 2012 Sep 15;99:186-93. DOI:10.1016/j.talanta.2012.05.038