3-AMINO-5-CYANO-BENZOIC ACID METHYL ESTER Chemical Properties

Melting point:

128°C

Boiling point:

371.5±27.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

1?+-.0.10(Predicted)

Appearance

Yellow to brown Solid

Safety Information

HS Code 

2916399090

3-AMINO-5-CYANO-BENZOIC ACID METHYL ESTER Usage And Synthesis

Synthesis

General procedure for the synthesis of methyl 3-amino-5-cyanobenzoate from methyl 3-cyano-5-nitrobenzoate: 10% Pd/C catalyst (0.9 g) was added to a mixed solution of methanol (200 mL) and tetrahydrofuran (100 mL) containing methyl 3-cyano-5-nitrobenzoate (25 mmol). Subsequently, the reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford methyl 3-amino-5-cyanobenzoate in 95% yield.

References

[1] Patent: US2009/118292, 2009, A1. Location in patent: Page/Page column 29
[2] Chemistry - A European Journal, 2015, vol. 21, # 52, p. 19231 - 19242
[3] Angewandte Chemie - International Edition, 2004, vol. 43, # 48, p. 6649 - 6652
[4] Patent: WO2011/137587, 2011, A1. Location in patent: Page/Page column 55

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