2-(4-morpholinyl)-4-pyridinylamine Chemical Properties

Boiling point:

414.4±45.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

solid

pka

9.35±0.10(Predicted)

Appearance

White to off-white Solid

InChI

1S/C9H13N3O/c10-8-1-2-11-9(7-8)12-3-5-13-6-4-12/h1-2,7H,3-6H2,(H2,10,11)

InChIKey

ZSXQDGMZXKOADT-UHFFFAOYSA-N

SMILES

Nc1ccnc(c1)N2CCOCC2

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

WGK 3

HS Code 

2934999090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

2-(4-morpholinyl)-4-pyridinylamine Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-morpholin-4-aminopyridine from morpholine and 2-chloro-4-aminopyridine: 2-chloro-4-aminopyridine (5.0 g, 38.9 mmol) was suspended in aminomethanol (13 mL) and heated in a microwave reactor for 1 hr at 200 °C. Upon completion of the reaction, the mixture was cooled to room temperature and a precipitate was observed to be generated. Ether (45 mL) was added to the mixture, stirred for 10 minutes and filtered. The filter cake was washed with ether and dried to give the target product 2-morpholin-4-amine pyridine (6.61 g, 95% yield).

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 51
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 34, p. 11035 - 11039
[3] Angew. Chem., 2018, vol. 130, # 34, p. 11201 - 11205,5
[4] Patent: US2005/65151, 2005, A1. Location in patent: Page/Page column 6; 14
[5] Patent: WO2017/93718, 2017, A1. Location in patent: Page/Page column 64

2-(4-morpholinyl)-4-pyridinylamine(35980-77-9)Related Product Information

• AURORA KA-5131
• AURORA KA-5223
• 2-(4-morpholinyl)-4-pyridinylamine
• 4-(4-ISOCYANATOPYRID-2-YL)MORPHOLINE