MMP SUBSTRATE III, FLUOROGENIC Chemical Properties

Density 

1.40±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble
Tris-buffered saline, pH 7.6: soluble

form 

lyophilized solid

pka

-0.26±0.40(Predicted)

color 

red

Sequence

{DABCYL-GABA}-Pro-Gln-Gly-Leu-Glu-{EDANS}-Ala-Lys-NH2

Safety Information

WGK Germany 

WGK 1

Storage Class

11 - Combustible Solids

MMP SUBSTRATE III, FLUOROGENIC Usage And Synthesis

Uses

TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

Biological Activity

Cell permeable: no', 'Primary Target
Detection of MMP activity', 'Product does not compete with ATP.', 'Reversible: no

MMP SUBSTRATE III, FLUOROGENIC(193475-71-7)Related Product Information

• MMP SUBSTRATE III, FLUOROGENIC
• 4-DIMETHYLAMINO-4'-METHYLAZOBENZENE