SULINDAC SULFIDE
SULINDAC SULFIDE Basic information
- Product Name:
- SULINDAC SULFIDE
- Synonyms:
-
- (Z)-5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
- (Z)-5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)-1H-INDEN-3-YLACETIC ACID
- 5-Fluoro-2-methyl-1-[(Z)-[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
- (Z)-Sulindac sulfide
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-
- Einecs 256-403-9
- SULINDAC SULPHIDE
- (Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID
- CAS:
- 49627-27-2
- MF:
- C20H17FO2S
- MW:
- 340.41
- EINECS:
- 256-403-9
- Product Categories:
-
- Intermediates & Fine Chemicals
- Metabolites
- Pharmaceuticals
- Mol File:
- 49627-27-2.mol
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SULINDAC SULFIDE Chemical Properties
- Melting point:
- 189-191°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO: >22 mg/mL
- form
- solid
- color
- yellow
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-42/43-63
- WGK Germany
- 3
- HS Code
- 2930902000
MSDS
- Language:English Provider:SigmaAldrich
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SULINDAC SULFIDE Usage And Synthesis
Chemical Properties
Yellow Solid
Uses
An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
Definition
ChEBI: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
SULINDAC SULFIDESupplier
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