DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS Chemical Properties

Density 

1.46±0.1 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

50% acetic acid: 5mg/mL
DMSO: 5mg/mL

form 

lyophilized solid

pka

-0.26±0.40(Predicted)

color 

red

Sequence

{DABCYL}-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-{EDANS}

DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS Usage And Synthesis

Uses

DABCYL-TNF-α-EDANS (-4 to +6) (human) is a FRET peptide substrate of tumor necrosis factor convertase (TACE)[1].

Biological Activity

Cell permeable: no', 'Km = 19 μM as a fluorescence resonance energy transfer (FRET) peptide substrate for TACE', 'Primary Target
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE', 'Product does not compete with ATP.', 'Reversible: no

References

[1] Liepinsh E, et al. NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding. J Biol Chem. 2003 Jul 11;278(28):25982-9. DOI:10.1074/jbc.M302734200