N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Chemical Properties

Boiling point:

576.3±30.0 °C(Predicted)

Density 

1.328±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

ethanol: 1 mg/mL

pka

13.44±0.46(Predicted)

form 

A crystalline solid

color 

light tan

Safety Information

WGK Germany 

3

RTECS 

UU9780100

MSDS

• Language:English Provider:SigmaAldrich

N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Usage And Synthesis

Description

FG 7142 (ZK 39106; LSU-65) is a nonselective benzodiazepine inverse agonist with high affinity (Ki= 91 nM) for the α1 subunit-containing GABAA receptor. FG 7142 also modulates GABA-induced chloride flux (EC50=137 nM) at GABAA receptors expressing the α1 subunit. FG 7142 increases tyrosine hydroxylation and leads to upregulation of β-adrenergic receptors in mouse cerebral cortex.

Uses

FG 7142 is a benzodiazepine inverse agonist anxiogenic compound.

Definition

ChEBI: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide is a member of beta-carbolines.

Biological Activity

Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β -adrenoceptors in mouse cerebral cortex.

Biochem/physiol Actions

Benzodiazepine inverse receptor agonist; potent anxiogenic agent.

storage

Store at RT

N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE(78538-74-6)Related Product Information

• Deionized water
• (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
• N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE
• 9H-PYRIDO[3,4-B]INDOLE
• ZERENEX E/6026476
• N-(4-CHLOROPHENYL)-1-METHYL-9H-BETA-CARBOLINE-3-CARBOXAMIDE
• N-(2,4-DIMETHYLPHENYL)-1-METHYL-9H-BETA-CARBOLINE-3-CARBOXAMIDE
• 1-METHYL-N-(5-PHENYL-1,3,4-THIADIAZOL-2-YL)-9H-BETA-CARBOLINE-3-CARBOXAMIDE
• 2-([(1-METHYL-9H-BETA-CARBOLIN-3-YL)CARBONYL]AMINO)BENZOIC ACID
• N-(2,3-DIMETHYLPHENYL)-1-METHYL-9H-BETA-CARBOLINE-3-CARBOXAMIDE
• ZERENEX E/6026463
• ZERENEX E/6026469
• ZERENEX E/6026461
• 1-METHYL-N-(2-METHYLPHENYL)-9H-BETA-CARBOLINE-3-CARBOXAMIDE
• N-(2,5-DIMETHYLPHENYL)-1-METHYL-9H-BETA-CARBOLINE-3-CARBOXAMIDE
• ZERENEX E/6026467
• ZERENEX E/6026471