D609
D609 Basic information
- Product Name:
- D609
- Synonyms:
-
- TRICYCLODECAN-9-YL XANTHOGENATE K
- TRICYCLODECAN-9-YL XANTHOGENATE POTASSIUM SALT
- D609, Potassium Salt - CAS 83373-60-8 - Calbiochem
- CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) ESTER POTASSIUM
- D609
- D-609 POTASSIUM
- D609 POTASSIUM SALT
- O-TRICYCLO[5.2.1.0(2,6)]DEC-9-YL DITHIOCARBONATE POTASSIUM SALT
- CAS:
- 83373-60-8
- MF:
- C11H17KOS2
- MW:
- 268.47
- EINECS:
- 280-379-9
- Product Categories:
-
- Lipid signaling
- Mol File:
- 83373-60-8.mol
D609 Chemical Properties
- storage temp.
- 0-6°C
- solubility
- H2O: 300 mg/mL
- form
- solid
- color
- off-white
- Water Solubility
- Soluble to 100 mM in water
MSDS
- Language:English Provider:SigmaAldrich
D609 Usage And Synthesis
Description
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
Chemical Properties
white to off-white solid
Uses
D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.
Biological Activity
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .
Biochem/physiol Actions
D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.
storage
Desiccate at -20°C
References
1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.
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D609(83373-60-8)Related Product Information
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- POTASSIUM ISOAMYLXANTHATE
- Tetrahydrocyclopentadiene
- D609
- potassium O-octyl dithiocarbonate
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- TS-609,flocculant TS-609
- EINECS 203-609-1
- Cyastat 609
- caswellno60
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- 2-CYCLOPENTYL CYCLOPENTANOL
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- N-PROPYLXANTHIC ACID POTASSIUM SALT
- BICYCLO[2.2.1]HEPTAN-2-OL