6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Chemical Properties

Boiling point:

353.4±22.0 °C(Predicted)

Density 

1.49

storage temp. 

Sealed in dry,Room Temperature

pka

3.48±0.10(Predicted)

InChI

InChI=1S/C11H12BrFN2/c1-6(2)15-7(3)14-11-9(13)4-8(12)5-10(11)15/h4-6H,1-3H3

InChIKey

SJQZRZLUEGCXFN-UHFFFAOYSA-N

SMILES

C1(C)N(C(C)C)C2=CC(Br)=CC(F)=C2N=1

Safety Information

HS Code 

2933998090

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Usage And Synthesis

Uses

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is a pharmaceutical intermediate. It can be used in the preparation of Abemaciclib, a kinase inhibitor for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer who have experienced disease progression following endocrine therapy and prior chemotherapy.

Flammability and Explosibility

Not classified

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole(1231930-33-8)Related Product Information

• 6-BroMo-4-fluoro-3-Methylindazole
• PERFLUOROPOLYALKYL ETHER
• GALDEN (TM) HT70
• Hexafluoroisopropyl methyl ether
• 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
• 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
• PF-01367338
• 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
• 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde
• 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-