MALEIC ANHYDRIDE (1,4-13C2)
MALEIC ANHYDRIDE (1,4-13C2) Basic information
- Product Name:
- MALEIC ANHYDRIDE (1,4-13C2)
- Synonyms:
-
- MALEIC ANHYDRIDE (1,4-13C2)
- SUCCINIC ANHYDRIDE (1,4-13C2, 99%)
- Succinic anhydride (1,2,3,4-13C?, 99%)
- Succinic anhydride (1,4-13C?, 99%)
- CAS:
- 67519-25-9
- MF:
- C4H2O3
- MW:
- 100.07
- Product Categories:
-
- Alphabetical Listings
- Metabolic Research
- MStable Isotopes
- Other
- Stable Isotopes
- Mol File:
- Mol File
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MALEIC ANHYDRIDE (1,4-13C2) Chemical Properties
- Melting point:
- 51-56 °C(lit.)
- Boiling point:
- 200 °C(lit.)
- form
- solid
- CAS Number Unlabeled
- 108-30-5
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Safety Information
- Hazard Codes
- C
- Risk Statements
- 22-34-42/43
- Safety Statements
- 22-26-36/37/39-45
- RIDADR
- UN 2215 8/PG 3
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MALEIC ANHYDRIDE (1,4-13C2) Usage And Synthesis
Uses
Succinic anhydride-13C2 is the 13C labeled Succinic anhydride[1]. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.