5-Amino-3-phenyl-1,2,4-thiadiazole Chemical Properties

Melting point:

152-156 °C

Density 

1.2353 (rough estimate)

refractive index 

1.5700 (estimate)

storage temp. 

2-8°C

form 

powder

color 

White

InChI

InChI=1S/C8H7N3S/c9-8-10-7(11-12-8)6-4-2-1-3-5-6/h1-5H,(H2,9,10,11)

InChIKey

OYAHSBDYBOBAAQ-UHFFFAOYSA-N

SMILES

S1C(N)=NC(C2=CC=CC=C2)=N1

CAS DataBase Reference

17467-15-1(CAS DataBase Reference)

EPA Substance Registry System

1,2,4-Thiadiazol-5-amine, 3-phenyl- (17467-15-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22-41-22

Safety Statements 

36/37/39-26-22

HazardClass 

IRRITANT

HS Code 

29341000

MSDS

• Language:English Provider:ACROS

5-Amino-3-phenyl-1,2,4-thiadiazole Usage And Synthesis

Description

5-Amino-3-phenyl-1,2,4-thiadiazole is an important organic synthetic reagent with remarkable reactivity and stability and has been used in the synthesis of a variety of heterocyclic compounds including 1,2,4-triazol-3-ylphenyls, derivatives of 2-aryl-5-amino-thiadiazole, 5-amino-1,2,4-thiadiazol-3-phenyls, and 5 -amino-1,2,4-thiadiazole-3-phenyl-3-methyl derivatives. It is also used in the synthesis of polymers such as poly(5-amino-3-phenyl-1,2,4-thiadiazole). In addition, 5-amino-3-phenyl-1,2,4-thiadiazole is an inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). The compound inhibits the release of pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β).

Chemical Properties

LIGHT BROWNISH FINE CRYSTALLINE POWDER

Uses

3-Phenyl-1,2,4-thiadiazol-5-amine is used as a reactant in the preparation of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

5-Amino-3-phenyl-1,2,4-thiadiazole(17467-15-1)Related Product Information

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