Voriconazole-d3 Chemical Properties

Boiling point:

508.6±60.0 °C(Predicted)

Density 

1.42±0.1 g/cm3(Predicted)

pka

11.54±0.29(Predicted)

Voriconazole-d3 Usage And Synthesis

Description

Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.

Uses

Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.

Application

Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.

References

1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Voriconazole-d3(188416-29-7)Related Product Information

• 4-Ethyl-5-fluoropyrimidine
• Voriconazole Impurity 16
• Ethanone, 1-(3,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-
• 1-Butanesulfonic acid, 4-hydroxy-, methyl ester
• Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI)
• Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro-
• 1,2,4-Triazole
• Voriconazole Impurity 53
• Voriconazole
• (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• ent-Voriconazole
• FENOFIBRIC ACID ETHYL ESTER
• (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
• 4-Ethyl-5-fluoro-6-hydroxypyrimidine
• 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine
• 2-Chloro-2',4'-difluoroacetophenone