5-Chloroisatoic anhydride Chemical Properties

Melting point:

300 °C (dec.) (lit.)

Density 

1.540±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly)

form 

Solid

pka

9.76±0.20(Predicted)

color 

Off-White

CAS DataBase Reference

4743-17-3(CAS DataBase Reference)

EPA Substance Registry System

2H-3,1-Benzoxazine-2,4(1H)-dione, 6-chloro- (4743-17-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2934999090

MSDS

• Language:English Provider:SigmaAldrich

5-Chloroisatoic anhydride Usage And Synthesis

Chemical Properties

White powder

Uses

5-Chloroisatoic Anhydride was used as a reagent in the synthesis of 2-acetamidobenzamides bearing the 2-phenoxy functionality which display antiproliferative activity against certain tumor cell lines. Also used in the preparation of inhibitors of delta-5 desaturase.

Preparation

5-Chloroisatoic anhydride is prepared from 5-chloro indole (9c) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
¹ H NMR (DMSO-d6): δ 11.85 (s, br., 1H), 7.96 (dd, J = 0.8, 8.7 Hz, 1H), 7.87 (dd, J = 2.3, 8.7 Hz, 1H), 7.09 (dd, J = 8.8, 0.8 Hz, 1H).

5-Chloroisatoic anhydride(4743-17-3)Related Product Information

• Metribuzin
• Erythromycin Estolate
• Di-tert-butyl dicarbonate
• Isatoic Anhydride
• Indirubin
• CREATININE-D3
• Buprofezin
• CIS-BUTENEDIOIC ANHYDRIDE
• Hydrochlorothiazide
• Trifluoromethanesulfonic anhydride
• Sulfachloropyridazine sodium
• Sulfachoropyrazine sodium
• Chromium(VI) oxide
• Phthalic anhydride
• Acetic anhydride
• 6-CHLOROISATIN
• Difluorochloromethane
• 6-chloro-1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione