Kansuinine B
Kansuinine B Basic information
- Product Name:
- Kansuinine B
- Synonyms:
-
- Kansuinine B
- Kansuinin B
- 2H-Cyclopenta[5,6]cyclododec[1,2-b]oxirene-3,11(1aH,4H)-dione, 8,10a-bis(acetyloxy)-5,7-bis(benzoyloxy)decahydro-4,9,10-trihydroxy-2,2,9,12-tetramethyl-6-methylene-, (1aS,4R,5S,7R,7aS,8R,9R,10S,10aS,12S,12aS)-
- Kansuinine B,SARS coronavirus,Interleukin Related,SARS-CoV,Inhibitor,inhibit
- (1aS,4R,5S,7R,7aS,8R,9R,10S,10aS,12S,12aS)-8,10a-Diacetoxy-4,9,10-trihydroxy-2,2,9,12-tetramethyl-6-methylene-3,11-dioxotetradecahydro-2H-cyclopenta[5,6]cyclododeca[1,2-b]oxirene-5,7-diyl dibenzoate
- CAS:
- 57685-46-8
- MF:
- C38H42O14
- MW:
- 722.73
- Mol File:
- 57685-46-8.mol
Kansuinine B Chemical Properties
- storage temp.
- 4°C, away from moisture
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to off-white
Kansuinine B Usage And Synthesis
Description
Kansuinine B shows cytotoxic activity. Kansuinine B shows analgesic activity. 3. Treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects.
Uses
Kansuinine B inhibits IL-6-induced Stat3 activation. Kansuinine B possesses anti-viral activity and could be used in the study for COVID-19[1][2][3].
Definition
ChEBI: Kansuinine B is a benzoate ester.
target
IL Receptor | STAT | ERK | MEK
References
[1] Jong Sun Chang, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010 Oct;76(14):1544-9. DOI:10.1055/s-0030-1249805
[2] Xiaoyun Shu, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. J Nat Med. 2010 Jan;64(1):98-103. DOI:10.1007/s11418-009-0366-0
[3] YASER DAANIAL , et al. PROMISING COMPOUNDS FOR TREATMENT OF COVID-19. VAWKUM Transactions on Computer Sciences, ISSN(e):2308-8168, ISSN(p): 2411-6335. Volume 17, Number 1, January-June, 2020.
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