Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester Chemical Properties

form 

Solid

color 

White to light yellow

InChIKey

RPNGUSKTYYIUDE-UHFFFAOYSA-N

SMILES

C(ON1C(=O)CCC1=O)(=O)CCSSCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O

Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester Usage And Synthesis

Uses

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-CONH-S-S-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Biological Activity

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

target

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Azadibenzocyclooctyne-CONH-N-hydroxysuccinimidyl ester(1435934-53-4)Related Product Information

• Ir[dF(Me)ppy]2(dtbbpy)PF6
• (2,2'-bipyrazine) (2,2'-linked (4-methylpyridine)) ruthenium hexafluoroborate
• DBCO-TCO
• Bis (2,2'-bipyridyl) (2,2'-bipyrimidine) ruthenium tetrafluoroborate