AZD-4694
AZD-4694 Basic information
- Product Name:
- AZD-4694
- Synonyms:
-
- AZD-4694
- 5-Benzofuranol, 2-[2-fluoro-6-(methylamino)-3-pyridinyl]-
- Flutafuranol
- NAV 4694
- NAV4694
- NAV-4694
- CAS:
- 1054629-49-0
- MF:
- C14H11FN2O2
- MW:
- 258.25
- Mol File:
- 1054629-49-0.mol
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AZD-4694 Chemical Properties
- Boiling point:
- 457.2±45.0 °C(Predicted)
- Density
- 1.381±0.06 g/cm3(Predicted)
- pka
- 8.86±0.40(Predicted)
- form
- Solid
- color
- White to off-white
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AZD-4694 Usage And Synthesis
Uses
AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1].
in vivo
Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1].
| Animal Model: | Male Sprague–Dawley rats (275-300 g)[1] |
| Dosage: | 4 mL/kg |
| Administration: | I.v. |
| Result: | Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients. |
References
[1] Juréus A, Swahn BM, Sandell J, et al. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010;114(3):784-794. DOI:10.1111/j.1471-4159.2010.06812.x
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