1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl ester
1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl ester Basic information
- Product Name:
- 1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl ester
- Synonyms:
-
- 1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl ester
- AU-224
- AU224,AU 224
- CAS:
- 287399-47-7
- MF:
- C19H28ClN3O4
- MW:
- 397.89632
- Mol File:
- 287399-47-7.mol
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1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl ester Chemical Properties
- Boiling point:
- 523.2±50.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.59±0.20(Predicted)
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1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl ester Usage And Synthesis
Uses
AU-224 is a benzamide derivative used as a promising gastrointestinal prokinetic agent without significant side effects.
Definition
ChEBI: CX-516 is a N-acylpiperidine.
in vivo
AU-224 has excellent effect of promoting digestive motion while showing little side effect and can be orally administered[1]. AU-224 shows only weak gastrointestinal prokinetic activity after oral administration due to its low lipophilicity[2].
References
[1] WO/2000/046201A1
[2] Sakaguchi J, et al. An improved synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (AU-224). Chem Pharm Bull (Tokyo). 2001 Jun;49(6):788-90. DOI:10.1248/cpb.49.788
1-Piperidineacetic acid, 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-, butyl esterSupplier
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