Methanone, (5-chloro-2-fluorophenyl)[(3S)-3-[[4-(3-cyclopropyl-3-fluoro-1-azetidinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]oxy]-1-pyrrolidinyl]- Chemical Properties

Boiling point:

786.4±70.0 °C(Predicted)

Density 

1.51±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

14.00±0.10(Predicted)

Methanone, (5-chloro-2-fluorophenyl)[(3S)-3-[[4-(3-cyclopropyl-3-fluoro-1-azetidinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]oxy]-1-pyrrolidinyl]- Usage And Synthesis

Uses

Aurora B Inhibitor 1 is used in methods of treating fibrosis using aurora kinase B (AURKB) inhibitors.

IC 50

Aurora B: 0.01 μM (Ki)