Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)- Chemical Properties

Boiling point:

661.7±55.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

11.20±0.20(Predicted)

Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)- Usage And Synthesis

Uses

(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

in vivo

IC 50

5-HT₂ Receptor; α1

References

[1] Mizuno A, et al. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56. DOI:10.1248/cpb.47.246