Remeglurant
Remeglurant Basic information
- Product Name:
- Remeglurant
- Synonyms:
-
- Remeglurant
- Methanone, (6-bromopyrazolo[1,5-a]pyrimidin-2-yl)[(1R)-3,4-dihydro-1-methyl-2(1H)-isoquinolinyl]-
- CAS:
- 1309783-00-3
- MF:
- C17H15BrN4O
- MW:
- 371.23
- Mol File:
- 1309783-00-3.mol
More
Less
Remeglurant Chemical Properties
- Density
- 1.59±0.1 g/cm3(Predicted)
- pka
- -1.89±0.40(Predicted)
More
Less
Remeglurant Usage And Synthesis
Uses
Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD)[1][2].
IC 50
mGluR 5: 13 nM (IC50)
References
[1] Pamela R Westmark, et al. Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056. Neurobiol Dis. 2018 Nov:119:190-198. DOI:10.1016/j.nbd.2018.08.008
[2] Philippe Huot, et al. Targeting metabotropic glutamate receptors for the treatment of Parkinson's disease. Neurodegener Dis Manag. 2023 Aug;13(4):203-206. DOI:10.2217/nmt-2023-0016