PC DBCO-PEG4-NHS ester Chemical Properties

Density 

1.37±0.1 g/cm3(Predicted)

pka

15.14±0.46(Predicted)

form 

Solid

color 

White to light yellow

PC DBCO-PEG4-NHS ester Usage And Synthesis

Uses

PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. DOI:10.1016/j.chembiol.2020.07.020